Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Arch Pharm Res. 2012 Oct;35(10):1723-32. doi: 10.1007/s12272-012-1003-0. Epub 2012 Nov 9.

Synthesis and antitumor activity of novel diaryl ether hydroxamic acids derivatives as potential HDAC inhibitors.

Author information

  • 1Department of Organic Chemistry, China Pharmaceutical University, Nanjing, China.

Abstract

A series of diaryl ether hydroxamic acids were synthesized for the first time and evaluated for the HDAC biology and antiproliferative activity. The structures of these new hydroxamic acids derivatives were confirmed by IR, (1)H-NMR and mass spectrum. Some of these compounds showed micro molar activity in the HDAC inhibitory assay and against four cancer cell lines.

PMID:
23139122
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Write to the Help Desk