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Zhonghua Yi Xue Za Zhi. 2012 Jul 17;92(27):1886-8.

[Correlation of the expression of NF-κB p65 and hepatic fibrosis in hepatitis patients].

[Article in Chinese]

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  • 1Department of Infectious Diseases, First Affiliated Hospital, Xinxiang Medical University, Henan 453100, China.



To explore the relationship between the expression of NF-κB p65 and hepatic fibrosis in chronic hepatitis B (CHB) patients.


Sixty CHB patients with hepatic fibrosis underwent liver biopsy to determine the stages of liver fibrosis (S0-S4). The distribution and expression of collagens I, III and NF-κB p65 in different stages of fibrosis in liver tissue were observed by immunohistochemistry and the results analyzed statistically.


The expression of NF-κB p65 was positively correlated with the stage of hepatic fibrosis. That was S4 > S3 > S2 > S1 (S0) (P < 0.01). And it was also positively correlated with the expression of collagens I and III (P < 0.01).


The elevated expression of NF-κB p65 is closely associated with the occurrence and development of hepatic fibrosis. Its mechanism is probably related with the increased secretion of collagens I and III after the activation of hepatic stellate cell.

[PubMed - indexed for MEDLINE]
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