How to stop: the mysterious links among RNA polymerase II occupancy 3' of genes, mRNA 3' processing and termination

Transcription. 2013 Jan-Feb;4(1):7-12. doi: 10.4161/trns.22300. Epub 2012 Nov 6.

Abstract

Eukaryotic genes are transcribed by RNA polymerase II (RNAP II) through cycles of initiation, elongation and termination. Termination remains the least understood stage of transcription. Here we discuss the role of RNAP II occupancy downstream of the 3'ends of genes and its links with termination and mRNA 3' processing.

Keywords: End of Annotated Gene; RNA Polymerase II pause; core histone genes; genome-wide mapping; polyadenylation; transcription termination.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Histones / genetics
  • Histones / metabolism
  • Humans
  • Polyadenylation
  • RNA Polymerase II / metabolism*
  • RNA Processing, Post-Transcriptional*
  • RNA, Messenger / genetics*
  • RNA, Messenger / metabolism*
  • Transcription Termination, Genetic*

Substances

  • Histones
  • RNA, Messenger
  • RNA Polymerase II