Eukaryotic genes are transcribed by RNA polymerase II (RNAP II) through cycles of initiation, elongation and termination. Termination remains the least understood stage of transcription. Here we discuss the role of RNAP II occupancy downstream of the 3'ends of genes and its links with termination and mRNA 3' processing.
Keywords: End of Annotated Gene; RNA Polymerase II pause; core histone genes; genome-wide mapping; polyadenylation; transcription termination.