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Future Oncol. 2012 Oct;8(10):1349-59. doi: 10.2217/fon.12.98.

EDIM-TKTL1 blood test: a noninvasive method to detect upregulated glucose metabolism in patients with malignancies.

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  • 1TAVARLIN AG, Landwehrstrasse 54, D-64293 Darmstadt, Germany. o.feyen@tavarlin.de

Abstract

AIM:

To determine whether the TKTL1 protein epitope detection in monocytes (EDIM) test allows detection of upregulated glucose metabolism in malignancies.

MATERIALS & METHODS:

The EDIM-TKTL1 blood test was conducted in 240 patients with 17 different confirmed or suspected malignancies. Test scores were compared with (18)F-fluoro-2-deoxy-D-glucose (FDG)-PET/computed tomography (CT) results.

RESULTS:

EDIM-TKTL1 score and FDG-PET results showed a concordance of 90% with a sensitivity of 94% and specificity of 81%. Including CT data, all values were enhanced. A subgroup analysis of non-small-cell lung cancer patients showed a significant correlation between the EDIM-TKTL1 score and the primary tumor size determined by FDG-PET/CT.

CONCLUSION:

EDIM-TKTL1 blood test revealed good concordance with FDG-PET/CT results in patients with malignancies demonstrating its efficacy to detect upregulation of glucose metabolism in primary tumors or metastases.

PMID:
23130932
[PubMed - indexed for MEDLINE]
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