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Neurosci Lett. 2012 Dec 7;531(2):166-9. doi: 10.1016/j.neulet.2012.10.044. Epub 2012 Nov 2.

Anxiolytic and hypnotic effects in mice of roasted coffee bean volatile compounds.

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  • 1Department of Foods and Human Nutrition, Faculty of Human Life Sciences, Notre Dame Seishin University, 2-16-9 Ifuku-cho, Kita-Ku, Okayama 700-8516, Japan.


To clarify the relationship between the volatile compounds present in roasted coffee beans and psychological stress, we investigated the stress-reducing potential of coffee volatiles in mice using a variety of behavioral pharmacology methods. In the elevated plus-maze test, exposure to coffee volatiles increased the time spent in and the number of entries into the open arms without increasing spontaneous locomotor activity. Pentobarbital-induced sleep time was prolonged by volatile exposure. No significant effects were detected in the open-field or forced-swim tests. These results suggest that coffee volatiles lower the arousal level and exert anti-anxiety-like, stress-reducing effects in mice.

Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

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