Send to:

Choose Destination
See comment in PubMed Commons below
J Safety Res. 2012 Sep;43(4):283-9. doi: 10.1016/j.jsr.2012.08.009. Epub 2012 Aug 25.

Prescription drug overdoses: a review.

Author information

  • 1Division of Unintentional Injury Prevention, National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, CDC El Paso Quarantine Station, 601 Sunland Park Drive, Suite 200, El Paso, TX 79912, USA.



Overdoses involving prescription drugs in the United States have reached epidemic proportions over the past 20 years.


This review categorizes and summarizes literature on the topic dating from the first published reports through 2011 using a traditional epidemiologic model of host, agent, and environment.


Host factors include male sex, middle age, non-Hispanic white race, low income, and mental health problems. Agent risk factors include use of opioid analgesics and benzodiazepines, high prescribed dosage for opioid analgesics, multiple prescriptions, and multiple prescribers. Environmental factors include rural residence and high community prescribing rates.


The epidemiology of prescription drug overdoses differs from the epidemiology of illicit drug overdoses. Incomplete understanding of prescription overdoses impedes prevention efforts.


This epidemic demands additional attention from injury professionals.

Published by Elsevier Ltd.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk