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Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2012 Nov;28(11):1138-41.

[Effect of dexamethasone on expressions of TWEAK and Fn14 in the lung of asthmatic mice].

[Article in Chinese]

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  • 1Department of Respiratory Diseases, Southern Medical University, Guangzhou, China.



To investigate the effect of dexamethasone (Dex) on the expressions of TNF-like weak inducer of apoptosis (TWEAK) and fibroblast growth factor-inducible immediate-early response protein 14 (Fn14) in the lung of asthmatic mice.


Ovalbumin (OVA) was used to induce asthma in BALB/c mice. Thirty-six female mice were randomly divided into control group (n=12), asthmatic group (n=12) and Dex treated group (n=12). The airway inflammation was evaluated by HE staining. The expressions of TWEAK and Fn14 at mRNA and protein levels were detected by RT-PCR and immunohistochemistry, respectively.


Both mRNA and protein levels of TWEAK and Fn14 in the asthmatic model group were significantly higher than those of control group (P<0.01), and both mRNA and protein levels of TWEAK and Fn14 in the Dex treated group were significantly lower than those of asthmatic group (P<0.01).


Dex can reduce the airway inflammation through inhibiting the expressions of TWEAK and Fn14.

[PubMed - indexed for MEDLINE]
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