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ACS Med Chem Lett. 2012 Aug 28;3(10):818-822.

The Synthesis and Antimicrobial Activity of Heterocyclic Derivatives of Totarol.

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  • 1Department of Chemistry, One Shields Ave, University of California, Davis, CA 95616.

Abstract

The synthesis and antimicrobial activity heterocyclic analogs of the diterpenoid totarol are described. An advanced synthetic intermediate with a ketone on the A-ring is used to attach fused heterocycles and a carbon-to-nitrogen atom replacement is made on the B-ring by de novo synthesis. A-ring analogs with an indole attached exhibit, for the first time, enhanced antimicrobial activity relative to the parent natural product. Preliminary experiments demonstrate that the indole analogs do not target the bacterial cell division protein FtsZ as had been hypothesized for totarol.

PMID:
23119123
[PubMed]
PMCID:
PMC3483140
Free PMC Article

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