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Plant Cell. 2012 Oct;24(10):3949-65. doi: 10.1105/tpc.112.103010. Epub 2012 Oct 30.

Conserved noncoding sequences highlight shared components of regulatory networks in dicotyledonous plants.

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  • 1Warwick Systems Biology Centre, University of Warwick, Coventry CV4 7AL, United Kingdom.

Abstract

Conserved noncoding sequences (CNSs) in DNA are reliable pointers to regulatory elements controlling gene expression. Using a comparative genomics approach with four dicotyledonous plant species (Arabidopsis thaliana, papaya [Carica papaya], poplar [Populus trichocarpa], and grape [Vitis vinifera]), we detected hundreds of CNSs upstream of Arabidopsis genes. Distinct positioning, length, and enrichment for transcription factor binding sites suggest these CNSs play a functional role in transcriptional regulation. The enrichment of transcription factors within the set of genes associated with CNS is consistent with the hypothesis that together they form part of a conserved transcriptional network whose function is to regulate other transcription factors and control development. We identified a set of promoters where regulatory mechanisms are likely to be shared between the model organism Arabidopsis and other dicots, providing areas of focus for further research.

PMID:
23110901
[PubMed - indexed for MEDLINE]
PMCID:
PMC3517229
Free PMC Article
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