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Iran Red Crescent Med J. 2012 Aug;14(8):479-82. Epub 2012 Aug 30.

Investigate the Role of Glutathione S Transferase (GST) Polymorphism in Development of Hypertension in UAE Population.

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  • 1Rashid Hospital, Dubai Health Authority, Dubai, United Arab Emirates.

Abstract

BACKGROUND:

GST is a family of enzymes that are important in protection of the body against oxidative stress.

OBJECTIVES:

Investigate the association between GSTT1 and GSTM1 polymorphism and hypertension.

MATERIALS AND METHODS:

GSTT1 and GSTM1 genotypes were detected by PCR. The fragments were then analyzed by agarose gel electrophoresis.

RESULTS:

There is no significant association between GSTT1 & GSTM1 polymorphism and hypertension (OR = 2.4, P > 0.05 and OR = 1.6, P > 0.05)

CONCLUSIONS:

GSTT1 & GSTM1 polymorphism can be considered a risk factor for hypertension.

KEYWORDS:

Glutathione S-Transferase T1; Hypertension; Polymorphism, Genetic

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