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Indian J Clin Biochem. 2008 Jan;23(1):62-6. doi: 10.1007/s12291-008-0015-5. Epub 2008 Mar 6.

Protective influence of vitamin E on the antioxidant defence system in the whole blood and liver of normal and alloxan-induced diabetic rats.

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  • 1Department of Biochemistry, University of Ado-Ekiti, P.M.B. 5363, Ado-Ekiti, Nigeria.

Abstract

The effect of oral administration of vitamin E for twenty-eight consecutive days on blood glucose, reduced glutathione levels, antioxidant enzymes (superoxide dismutase and catalase activities), and levels of malondialdehyde (as an index of free radical-mediated lipid peroxidation) was observed in the whole blood and liver of normal and alloxan-induced diabetic rats. It was found that oral administration of vitamin E significantly (p<0.05) lowered the blood glucose level and increased the body weight of the diabetic rats. The activities of superoxide dismutase and levels of reduced glutathione increased significantly (p<0.05) while the level of lipid peroxidation decreased.

KEYWORDS:

Antioxidant enzymes; Diabetes; Lipid Peroxidation; Reduced glutathione; Vitamin E

PMID:
23105723
[PubMed]
PMCID:
PMC3453651
Free PMC Article
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