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Fitoterapia. 2013 Jan;84:54-7. doi: 10.1016/j.fitote.2012.10.013. Epub 2012 Oct 24.

Sinoscrewtine, an alkaloid with novel skeleton from the roots of Sinomenium acutum.

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  • 1Key Laboratory of Phytochemistry of Shaanxi Province, Baoji University of Arts and Sciences, Baoji 721013, China. xlwangwang@163.com

Abstract

An alkaloid with novel skeleton, sinoscrewtine (1), has been isolated from the roots of Sinomenium acutum. Its structure was established by spectral analysis and X-ray crystallographic study, and its possible biosynthetic pathway was delivered. In vitro experiments, 1 showed weak injurious effects against H(2)O(2)/Aβ(25-35) induced oxidative injury in PC-12 cells and DPPH radical scavenging activity with IC(50) of 32.6μM.

Copyright © 2012 Elsevier B.V. All rights reserved.

PMID:
23103953
[PubMed - indexed for MEDLINE]
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