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Immunol Allergy Clin North Am. 2012 Nov;32(4):487-511. doi: 10.1016/j.iac.2012.08.005.


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  • 1Respiratory Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.


Sarcoidosis is a multisystem granulomatous syndrome with a vast range of clinical manifestations. Since the first description of sarcoidosis in 1869, it has simultaneously intrigued and perplexed generations of physicians. Because sarcoidosis can occur variably in any organ and does not always adhere to classic descriptions, both diagnosis of sarcoidosis and attribution of symptoms can be extremely challenging. The management of sarcoidosis requires consideration of the expected course. Medication is considered when there is risk of irreversible vital organ damage, substantial progression, or symptoms that are affecting quality of life. Recently, a range of steroid-sparing therapies have been adopted for sarcoidosis.

Copyright © 2012. Published by Elsevier Inc.

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