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Indian J Microbiol. 2009 Dec;49(4):332-8. doi: 10.1007/s12088-009-0059-0. Epub 2010 Jan 7.

Molecular events leading to the creation of a pandemic influenza virus.

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  • 1P. O. Box. 10504, ICGEB, Aruna Asaf Ali Road, New Delhi, 110067 India.


Influenza A virus is a potent pathogen of annual respiratory illness with huge potential of causing occasional pandemics of catastrophic consequences. In April 2009, a novel, swine-origin influenza A H1N1/09 virus was identified in Mexico which continued to spread globally. This unique virus emerged from an avian, human, Eurasian swine viral strain and a North American swine strain belonging to the lineage of the 1930 swine virus. Till date H1N1/09 pandemic has been relatively mild and lacks the previously described molecular markers of influenza A pathogenicity and transmissibility. In this review, we will discuss the molecular and antigenic determinants of this virus and its designation as a low pathogenic strain, which carries the potential to develop into a devastating strain with subsequent mutations and reassortments.


Antigenic determinants; H1N1; Pandemic; Pathogenicity

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