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Chem Commun (Camb). 2012 Dec 4;48(93):11461-3. doi: 10.1039/c2cc35567a. Epub 2012 Oct 23.

Delivery, stabilization, and spatiotemporal activation of cargo molecules in cells with positively charged nanoparticles.

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  • 1Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Japan.


Positively charged photodegradable nanoparticles that simultaneously encapsulated various compounds including small and large molecules were prepared. The nanoparticles were internalized to the cell by endocytosis and were stable within the cells for at least 4 days. The encapsulated molecules were released into the cytosol using light stimuli.

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