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FEBS Lett. 2012 Nov 30;586(23):4180-5. doi: 10.1016/j.febslet.2012.10.017. Epub 2012 Oct 23.

"η6"-Type anion-π in biomolecular recognition.

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  • 1Department of Chemistry and Biochemistry, South Dakota State University, Brookings, SD 57007, USA.


Theoretical and compelling experimental evidence indicates that the interaction between an anion and an aromatic π system when the anion is directly above the ring face ("η(6)"-type anion-π), can be attractive. This may play an important role in the formation and recognition of biomolecular structures. We examined high-resolution structures of proteins and nucleic acids for the presence of "η(6)"-type anion-π. Though less frequent than its counterpart cation-π, "η(6)"-type anion-π is observed unambiguously, occurring in protein/nucleic acid loops and often involving conserved/coevolving sites in proteins, suggesting it plays an important role in macromolecular folding and function.

Copyright © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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