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Clin Pharmacol Ther. 2012 Nov;92(5):546-8. doi: 10.1038/clpt.2012.145.

Prediction of transporter-mediated drug-drug interactions using endogenous compounds.

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  • Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander Universität Erlangen-Nürnberg, Germany. martin.fromm@pharmakologie.med.uni-erlangen.de


Therapy with two or more drugs is more the rule than the exception, particularly in aging societies. Drug-drug interactions are frequently undesirable and may lead to increased toxicity and mortality. Inhibition of transporters is one major mechanism underlying drug-drug interactions. The myriad of potential drug combinations makes it very challenging to predict drug-drug interactions. This Commentary discusses potential advantages and limitations of endogenous compounds for predicting transporter-mediated drug-drug interactions.

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