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Neuron. 2012 Oct 18;76(2):260-2. doi: 10.1016/j.neuron.2012.10.001. Epub 2012 Oct 17.

A prion-mediated mechanism for memory proposed in Drosophila.

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  • 1Laboratory of Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.

Abstract

Memories are remarkably persistent, but rely on transient signaling. The prion-like properties of CPEB suggested a solution to this problem. The paper by Krüttner et al. (2012) in this issue of Neuron demonstrates that the prion-like domain of Drosophila CPEB functions independently of its RNA-binding domain for memory.

Copyright © 2012 Elsevier Inc. All rights reserved.

PMID:
23083729
[PubMed]
PMCID:
PMC3488862
Free PMC Article
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