J Mol Biol. 1990 Feb 5;211(3):505-13.

Heterogenic mRNAs with an identical protein-coding region of the human embryonic myosin alkali light chain in skeletal muscle cells.

Zimmermann K, Kautz S, Hajdu G, Winter C, Whalen RG, Starzinski-Powitz A.

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Institut für Genetik, Forschungszentrum, Köln, FRG.

Abstract

The formation of human myotubes in culture is accompanied by the induction of developmentally regulated, muscle-specific genes. We have studied the expression of human myosin light chain proteins and mRNAs during myogenesis in culture, in particular the skeletal embryonic myosin light chain 1 (MC1emb), which is indistinguishable from MLC1 of adult atrial cardiac muscle (MLC1A) as has been shown for rodent and bovine MLC1emb. We have identified distinct MLC1emb/MLC1A mRNAs in cultured human skeletal muscle cells that differ in their 5' and 3' untranslated regions but contain identical protein-coding regions. The alternative 3' untranslated region is detectable also in RNA of human atria. The different MLC1emb RNAs are likely to be encoded by one gene. It appears that the two MLC1emb 5' untranslated regions of the human gene are specific for man. In the mouse, only one 5' untranslated region of the MLC1emb gene has been detected.

PMID:: 2308163; [PubMed - indexed for MEDLINE]

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Structure and sequence of the myosin alkali light chain gene expressed in adult cardiac atria and fetal striated muscle. [J Biol Chem. 1988]
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Barton PJ, Robert B, Cohen A, Garner I, Sassoon D, Weydert A, Buckingham ME. J Biol Chem. 1988 Sep 5; 263(25):12669-76.
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Cited by 4 PubMed Central articles

Myosin light chain 1 atrial isoform (MLC1A) is expressed in pre-B cells under control of the BOB.1/OBF.1 coactivator. [Nucleic Acids Res. 2004]
Myosin light chain 1 atrial isoform (MLC1A) is expressed in pre-B cells under control of the BOB.1/OBF.1 coactivator.
Laumen H, Brunner C, Greiner A, Wirth T. Nucleic Acids Res. 2004; 32(4):1577-83. Epub 2004 Mar 5.
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Morano M, Zacharzowski U, Maier M, Lange PE, Alexi-Meskishvili V, Haase H, Morano I. J Clin Invest. 1996 Jul 15; 98(2):467-73.
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Heterogenic mRNAs with an identical protein-coding region of the human embryonic...
Heterogenic mRNAs with an identical protein-coding region of the human embryonic myosin alkali light chain in skeletal muscle cells.
J Mol Biol. 1990 Feb 5 ;211(3):505-13.

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