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Sci Transl Med. 2012 Oct 17;4(156):156ps20. doi: 10.1126/scitranslmed.3005083.

Sisyphus and translational stroke research.

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  • 1Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.


After more than 1000 failures, we know that our methods for translating effective stroke treatments from the laboratory to the clinic do not work. New preclinical and clinical approaches conceived outside of the current paradigm exist and should be carefully considered. Now, Tymianski and colleagues report on results obtained during translation of a new neuroprotectant.

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