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J Clin Oncol. 2012 Dec 1;30(34):4262-6. doi: 10.1200/JCO.2012.42.1958. Epub 2012 Oct 15.

Role of comparative effectiveness research in cancer funding decisions in Ontario, Canada.

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  • 1Cancer Care Ontario and St Michael’s Hospital, Ontario, Canada.


Recently, the evidence-based drug funding process in Ontario, Canada, was challenged by a young mother with a breast tumor too small, based on the evidence that existed at the time, to qualify for an expensive drug. In reality, this is only the latest in a number of challenges the publicly funded health care system has had to deal with in the face of an evolving drug policy landscape. This article defines comparative effectiveness research (CER), considering how it is viewed differently in the United States and Canada. It also reviews the role CER now plays in the Ontario drug funding process and concludes with a review of the challenges and opportunities of using observational data to conduct CER and incorporate it into policy making within a universal health care system. Many of the issues faced by Ontario are relevant beyond Canada, including in the United States during this period of health care reform.

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