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Mol Biol Rep. 2013 Jan;40(1):255-62. doi: 10.1007/s11033-012-2056-3. Epub 2012 Oct 16.

Cervical cancer with polymorphism in MTHFR C677T gene: a systematic review and meta-analysis.

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  • 1Department of Health Informatics, School of Health Services Management, Anhui Medical University, 69 Meishan Road, Hefei 230032, Anhui, China.


To perform a meta-analysis investigating the association of MTHFR C677T polymorphism and susceptibility of cervical cancer. All case-control studies published in English and Chinese with estimates of the relationship between MTHFR C677T polymorphism and risk of cervical cancer were analyzed using odds ratio (OR) with 95 % confidence interval (CI). A total of 10 studies (2,023 cases and 2,570 controls) were included in the meta-analysis. No significant association was observed between T allele and C allele (OR = 0.90; 95 %CI = 0.70-1.17; P = 0.43), and for genotype TT versus CC (OR = 1.09; 95 %CI = 0.74-1.61; P = 0.67), CT versus CC (OR = 0.95; 95 %CI = 0.75-1.20; P = 0.65), CT + TT versus CC (OR = 0.91; 95 %CI = 0.66-1.24; P = 0.55). The current meta-analysis results suggest that the MTHFR C677T polymorphism may not be associated with cervical cancer.

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