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Antimicrob Agents Chemother. 2012 Dec;56(12):6432-3. doi: 10.1128/AAC.01079-12. Epub 2012 Oct 15.

Stability of colistimethate sodium in aqueous solution.

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  • 1Division of Infectious Diseases and HIV Medicine, Case Western Reserve University, Cleveland, OH, USA. amb233@case.edu

Abstract

Colistimethate sodium, increasingly used to treat multidrug-resistant Gram-negative infections, spontaneously hydrolyzes to form colistin A (polymyxin E1) and B (polymyxin E2/B) when mixed with water. High levels of these active breakdown products at the time of administration have been associated with nephrotoxicity and even death. In this study, reconstituted colistimethate sodium was shown to be stable (<1.0% colistin A/B formation) for up to 24 h when stored at 21, 0, -20, and -70°C.

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