Send to

Choose Destination
See comment in PubMed Commons below
Antimicrob Agents Chemother. 2012 Dec;56(12):6432-3. doi: 10.1128/AAC.01079-12. Epub 2012 Oct 15.

Stability of colistimethate sodium in aqueous solution.

Author information

  • 1Division of Infectious Diseases and HIV Medicine, Case Western Reserve University, Cleveland, OH, USA.


Colistimethate sodium, increasingly used to treat multidrug-resistant Gram-negative infections, spontaneously hydrolyzes to form colistin A (polymyxin E1) and B (polymyxin E2/B) when mixed with water. High levels of these active breakdown products at the time of administration have been associated with nephrotoxicity and even death. In this study, reconstituted colistimethate sodium was shown to be stable (<1.0% colistin A/B formation) for up to 24 h when stored at 21, 0, -20, and -70°C.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk