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J Invest Dermatol. 2012 Nov;132(11):2492-4. doi: 10.1038/jid.2012.322.

CD133 in the selection of epidermal stem cells in mice: steps in the right direction.

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  • 1Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, New York, USA.

Abstract

Charruyer and colleagues (this issue) report two significant advances to the field of cutaneous keratinocyte stem cells: a pair of new selectable markers that recognize a subset of α6(+)CD34(+) label-retaining cells, and an in vivo limiting dilution assay for keratinocyte stem cells with long-term repopulating ability. This work has important implications for keratinocyte stem cell identification and assay, as well as for the identification of target cells in non-melanoma skin cancer.

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