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J Pediatr. 2013 Jan;162(1):205-7. doi: 10.1016/j.jpeds.2012.08.035. Epub 2012 Oct 13.

Imatinib mesylate in the treatment of diffuse cutaneous mastocytosis.

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  • 1Department of Dermatology, Catholic University of Leuven and University Hospitals Leuven, Leuven, Belgium. Marie-Anne.Morren@uzleuven.be

Abstract

Diffuse cutaneous mastocytosis is a less common but potentially life-threatening variant of childhood mastocytosis. Here we report 2 children with diffuse cutaneous mastocytosis in whom an activating somatic KIT mutation was detected. Treatment with imatinib, a KIT inhibitor, resulted in resolution of the lesions and were well tolerated by the patients.

Copyright © 2013 Mosby, Inc. All rights reserved.

PMID:
23069194
[PubMed - indexed for MEDLINE]
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