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Front Cell Infect Microbiol. 2012 Oct 8;2:122. doi: 10.3389/fcimb.2012.00122. eCollection 2012.

Toll-like receptor sensing of human herpesvirus infection.

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  • 1Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill Chapel Hill, NC, USA; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill Chapel Hill, NC, USA.


Toll-like receptors (TLRs) are evolutionarily conserved pathogen sensors that constitute the first line of defense in the human immune system. Herpesviruses are prevalent throughout the world and cause significant disease in the human population. Sensing of herpesviruses via TLRs has only been documented in the last 10 years and our understanding of the relationship between these sentinels of the immune system and herpesvirus infection has already provided great insight into how the host cell responds to viral infection. This report will summarize the activation and modulation of TLR signaling in the context of human herpesvirus infections.


TLR; cytokines; herpesvirus; innate immunity; interferons

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