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Commun Integr Biol. 2012 Jul 1;5(4):334-6. doi: 10.4161/cib.20364.

Neuron-specific regulation on F-actin cytoskeletons: The role of CTTNBP2 in dendritic spinogenesis and maintenance.

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  • 1Institute of Molecular Biology; Institute of Molecular Biology; Academia Sinica; Taipei, Taiwan.

Abstract

Dendritic spines are neuron-specific actin-rich subcellular structures and are the location of excitatory synapses. Neurotransmitters released from presynaptic terminals activate the signals modifying the F-actin dynamics and stability and thus control dendritic spine morphology. Many ubiquitously expressed actin-associated proteins, including cortactin, have been shown to regulate dendritic spine morphology and density. Since dendritic spines are neuron-specific structures, neuron-specific proteins are expected to control F-actin cytoskeletons and dendritic spinogenesis. Recently, we demonstrated that cortactin-binding protein 2 (CTTNBP2), a neuron-specific protein, regulates the mobility and distribution of cortactin and controls the density of dendritic spines. This is the first example of a neuron-specific protein that controls the mobility of an F-actin associated protein and influences the dendritic spines. It provides a platform to explore the specific pathway triggering dendritic spinogenesis.

KEYWORDS:

CTTNBP2; CTTNBP2-NL; Cortactin; F-actin-associated protein; dendritic spine formation

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