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Front Immunol. 2012 Oct 4;3:313. doi: 10.3389/fimmu.2012.00313. eCollection 2012.

The intestinal B-cell response in celiac disease.

Author information

  • 1Centre for Immune Regulation, Department of Immunology, Oslo University Hospital-Rikshospitalet, University of Oslo, Oslo, Norway.

Abstract

The function of intestinal immunity is to provide protection toward pathogens while preserving the composition of the microflora and tolerance to orally fed nutrients. This is achieved via a number of tightly regulated mechanisms including production of IgA antibodies by intestinal plasma cells. Celiac disease is a common gut disorder caused by a dysfunctional immune regulation as signified, among other features, by a massive intestinal IgA autoantibody response. Here we review the current knowledge of this B-cell response and how it is induced, and we discuss key questions to be addressed in future research.

KEYWORDS:

B cells; autoantibodies; celiac disease; intestinal mucosa; mucosal immunity

PMID:
23060888
[PubMed]
PMCID:
PMC3463893
Free PMC Article

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