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Anticancer Res. 2012 Oct;32(10):4263-70.

uPA and uPA-receptor are involved in cancer-associated myeloid-derived suppressor cell accumulation.

Author information

  • 1Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, PO Box 016960, R-138, Miami, FL 33101, USA.

Abstract

BACKGROUND:

Myeloid-derived suppressor cells (MDSC) have been shown to play a critical role in tumor-induced immunosuppression, in many mouse and human cancers. The aim of this study was to show that MDSC accumulation is tumor burden-dependent, and to investigate the role of the tumor-derived urokinase plasminogen activator (uPA) and its receptor (uPAR) on MDSC recruitment.

MATERIALS AND METHODS:

Levels of MDSC were assessed in tumor-bearers, and the ability to recruit MDSC by uPA was investigated in normal, tumor-bearers, uPAR(-/-), and CD11b(-/-) mice. uPAR expression in MDSC was also explored.

RESULTS:

MDSC accumulate to dramatic levels in tumor-bearers, and tumor-derived factors such as uPA also increase to great levels in circulation. MDSC can be recruited by uPA, and uPAR but not CD11b are required for such recruitment.

CONCLUSION:

MDSC accumulation is tumor burden-dependent, and tumor-derived factors such as uPA and its receptor uPAR play a role in their recruitment.

PMID:
23060546
[PubMed - indexed for MEDLINE]
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