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Chembiochem. 2012 Nov 5;13(16):2335-8. doi: 10.1002/cbic.201200465. Epub 2012 Oct 11.

Direct observation of internalization and ROS generation of amyloid β-peptide in neuronal cells at subcellular resolution.

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  • 1Institute of Molecular Science, Key Laboratory of Chemical Biology and Molecular Engineering of the Ministry of Education, Shanxi University, Taiyuan 030006, P. R. China.

Abstract

Seeing in many colors: Confocal images acquired using fluorescently labeled amyloid β-peptide revealed its efficient internalization by endocytosis into endosomes/lysosomes of human neuronal cells with a small portion reaching mitochondria, inducing marked cellular and mitochondrial reactive oxygen species production.

Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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