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Planta Med. 2012 Nov;78(17):1873-7. doi: 10.1055/s-0032-1327785. Epub 2012 Oct 11.

New alkaloids and cytotoxic principles from Sinomenium acutum.

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  • 1National Research Institute of Chinese Medicine, Taipei, Taiwan.

Abstract

Two new alkaloids, 2-demethyl-oxypalmatine (1) and 5-ethoxycarbonylsinoracutine (2), were isolated from the rhizomes of Sinomenium acutum, along with thirty-four known compounds. Cytotoxicity of the isolated compounds was examined for the MCF-7, H460, HT-29, and CEM human cancer cell lines. Dauriporphine (16), 6-O-demethylmenisporphine (17), bianfugecine (18), menisporphine (19), and 6-O-demethyldauriporphine (20) showed differential effects in their cytotoxic activity on the target cancer cell lines. Significant angiogenesis inhibitions of 16 and 19 were also observed.

Georg Thieme Verlag KG Stuttgart ยท New York.

PMID:
23059629
[PubMed - indexed for MEDLINE]
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