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Korean J Pediatr. 2012 Sep;55(9):344-9. doi: 10.3345/kjp.2012.55.9.344. Epub 2012 Sep 14.

Urinary 6-sulfatoxymelatonin level in girls and its relationship with obesity.

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  • 1Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.



Short sleep duration is associated with obesity. Urinary 6-sulfatoxymelatonin (6-OHMS), the principal metabolite of melatonin, is closely related with sleep. We evaluated the difference in urinary 6-OHMS levels between obese girls and normal weight girls, and the relationship of urinary 6-OHMS with other hormones regulating body weight and metabolism.


A total of 79 girls (6.3 to 12.4 years) were included in this study, of whom 34 were obese; 15, overweight; and 30, normal-weight. We examined their pubertal status and bone age. Fasting serum levels of total ghrelin, leptin, insulin, and first morning urinary 6-OHMS were measured. Homeostatic model assessment-insulin resistance (HOMA-IR) was calculated from the fasting insulin and glucose levels.


There was no significant difference in the creatinine adjusted 6-OHMS levels between the obese girls and the control group. Urinary 6-OHMS did not show any correlations with body mass index (BMI), BMI percentile, total ghrelin, leptin, and HOMA-IR. Negative correlations were found between urinary 6-OHMS levels and chronological and bone ages.


Our results suggest that melatonin production is not reduced consistently in obese girls.


6-Sulfatoxymelatonin; Child; Melatonin; Obesity

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