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Rev Bras Hematol Hemoter. 2012;34(4):280-4. doi: 10.5581/1516-8484.20120072.

Association of HLA antigens and BCR-ABL transcripts in leukemia patients with the Philadelphia chromosome.

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  • 1Universidade Federal de Santa Maria - UFSM, Santa Maria, RS, Brazil.



This study aimed to verify the association between human leukocyte antigens and the bcr-abl fusion protein resulting from t(9;22)(q34;q11) in chronic leukemia myeloid and acute lymphoblastic leukemia patients.


Forty-seven bcr-abl positive individuals were evaluated. Typing was performed bymicrolymphocytotoxicity and molecular biological methods (human leukocyte antigens Class I and Class II). A control group was obtained from the data of potential bone marrow donors registered in the Brazilian Bone Marrow Donor Registry (REDOME).


Positive associations with HLA-A25 and HLA-B18 were found for the b2a2 transcript, as well as a tendency towards a positive association with HLA-B40 and a negative association with HLA-A68. The b3a2 transcript showed positive associations with HLA-B40 and HLA-DRB1*3.


The negative association between human leukocyte antigens and the BCR-ABL transcript suggests that binding and presentation of peptides derived from the chimeric protein are effective to increase a cytotoxic T lymphocyte response appropriate for the destruction of leukemic cells.


Fusion proteins, BCR-ABL; Genetic predisposition to disease; HLA antigens; Leukemia, myelogenous, chronic, BCR-ABL positive; Philadelphia chromosome; Precursor cell lymphoblastic leukemia-lymphoma

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