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J Dent Res. 2012 Dec;91(12):1172-7. doi: 10.1177/0022034512463240. Epub 2012 Oct 8.

Nano hydroxyapatite-coated implants improve bone nanomechanical properties.

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  • 1Department of Prosthodontics, Faculty of Odontology, Malmö University, Sweden. ryo.jimbo@mah.se

Abstract

Nanostructure modification of dental implants has long been sought as a means to improve osseointegration through enhanced biomimicry of host structures. Several methods have been proposed and demonstrated for creating nanotopographic features; here we describe a nanoscale hydroxyapatite (HA)-coated implant surface and hypothesize that it will hasten osseointegration and improve its quality relative to that of non-coated implants. Twenty threaded titanium alloy implants, half prepared with a stable HA nanoparticle surface and half grit-blasted, acid-etched, and heat-treated (HT), were inserted into rabbit femurs. Pre-operatively, the implants were morphologically and topographically characterized. After 3 weeks of healing, the samples were retrieved for histomorphometry. The nanomechanical properties of the surrounding bone were evaluated by nanoindentation. While both implants revealed similar bone-to-implant contact, the nanoindentation demonstrated that the tissue quality was significantly enhanced around the HA-coated implants, validating the postulated hypothesis.

PMID:
23045363
[PubMed - indexed for MEDLINE]
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