Appl Radiat Isot. 2012 Dec;70(12):2689-94. doi: 10.1016/j.apradiso.2012.08.005. Epub 2012 Aug 19.

Evaluation of dopamine transporters and D2 receptors in hemiparkinsonian rat brains in vivo using consecutive PET scans of [18F]FPCIT and [18F]fallypride.

Choi JY, Kim CH, Jeon TJ, Cho WG, Lee JS, Lee SJ, Choi TH, Kim BS, Yi CH, Seo Y, Yi DI, Han SJ, Lee M, Kim DG, Lee JD, An G, Ryu YH.

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Department of Pharmacology, Brain Research Institute, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea.

Abstract

The aim of this study was to investigate dopaminergic function in unilaterally lesioned 6-OHDA rats by dual PET radioligands: [(18)F]FPCIT (a dopamine transporter imaging radioligand) and [(18)F]fallypride (a dopamine D2 receptors imaging radioligand). As a result, the brain uptake of [(18)F]FPCIT was significantly reduced and that of [(18)F]fallypride was increased in the ipsilateral striatum (lesion side) of the 6-OHDA rats. These findings implicated that dopamine transporter is down-regulated and dopamine D2 receptor is up-regulated in this hemiparkinsonian rat model.

PMID:: 23041777; [PubMed - indexed for MEDLINE]

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Evaluation of dopamine transporters and D2 receptors in hemiparkinsonian rat bra...
Evaluation of dopamine transporters and D2 receptors in hemiparkinsonian rat brains in vivo using consecutive PET scans of [18F]FPCIT and [18F]fallypride.
Appl Radiat Isot. 2012 Dec ;70(12):2689-94. doi: 10.1016/j.apradiso.2012.08.005. Epub 2012 Aug 19 .

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Evaluation of dopamine transporters and D2 receptors in hemiparkinsonian rat brains in vivo using consecutive PET scans of [18F]FPCIT and [18F]fallypride.

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