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Angew Chem Int Ed Engl. 2012 Oct 29;51(44):11162-5. doi: 10.1002/anie.201203769. Epub 2012 Oct 4.

Isotope-based analysis of modified tRNA nucleosides correlates modification density with translational efficiency.

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  • 1Center for Integrated Protein Science at the Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, 81377 Munich, Germany.

Abstract

Useful diversity: Quantification of modified tRNA nucleobases in different murine and porcine tissues reveals a tissue-specific overall modification content. The modification content correlates with rates of protein synthesis in vitro, suggesting a direct link between tRNA modification levels and tissue-specific translational efficiency.

Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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