Send to

Choose Destination
See comment in PubMed Commons below
Angew Chem Int Ed Engl. 2012 Oct 29;51(44):11162-5. doi: 10.1002/anie.201203769. Epub 2012 Oct 4.

Isotope-based analysis of modified tRNA nucleosides correlates modification density with translational efficiency.

Author information

  • 1Center for Integrated Protein Science at the Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, 81377 Munich, Germany.


Useful diversity: Quantification of modified tRNA nucleobases in different murine and porcine tissues reveals a tissue-specific overall modification content. The modification content correlates with rates of protein synthesis in vitro, suggesting a direct link between tRNA modification levels and tissue-specific translational efficiency.

Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley Icon for PubMed Central
    Loading ...
    Write to the Help Desk