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Genet Med. 2013 Feb;15(2):115-22. doi: 10.1038/gim.2012.103. Epub 2012 Oct 4.

Getting our priorities straight: a novel framework for stakeholder-informed prioritization of cancer genomics research.

Author information

  • 1Center for Medical Technology Policy, Baltimore, MD, USA. laura.esmail@gmail.com

Abstract

PURPOSE:

Prioritization of translational research on genomic tests is critically important given the rapid pace of innovation in genomics. The goal of this study was to evaluate a stakeholder-informed priority-setting framework in cancer genomics.

METHODS:

An external stakeholder advisory group including patients/consumers, payers, clinicians, and test developers used a modified Delphi approach to prioritize six candidate cancer genomic technologies during a 1-day meeting. Nine qualitative priority-setting criteria were considered. We used a directed, qualitative content-analysis approach to investigate the themes of the meeting discussion.

RESULTS:

Stakeholders primarily discussed six of the original nine criteria: clinical benefits, population health impacts, economic impacts, analytical and clinical validity, clinical trial implementation and feasibility, and market factors. Several new priority-setting criteria were identified from the workshop transcript, including "patient-reported outcomes," "clinical trial ethics," and "trial recruitment." The new criteria were incorporated with prespecified criteria to develop a novel priority-setting framework.

CONCLUSION:

This study highlights key criteria that stakeholders can consider when prioritizing comparative effectiveness research for cancer genomic applications. Applying an explicit priority-setting framework to inform investment in comparative effectiveness research can help to ensure that critical factors are weighed when deciding between many potential research questions and trial designs.

PMID:
23037935
[PubMed - indexed for MEDLINE]
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