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J Clin Gastroenterol. 1990 Feb;12(1):40-1.

High-dose methylprednisolone in the treatment of active ulcerative colitis.

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  • 1Gastroenterology Unit, Radcliffe Infirmary, Oxford, U.K.


Twenty patients with severe active ulcerative colitis were entered into a pilot study to test the efficacy of pulsed high-dose methylprednisolone in inducing remission. Of 20 patients, 12 improved, but 8 of 20 patients (40%) who did not went for urgent colectomy. The group proceeding to surgery tended to have more extensive disease. These results contrast unfavorably with historical control data from this unit.

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