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Org Biomol Chem. 2012 Nov 21;10(43):8640-4. doi: 10.1039/c2ob26375k.

A highly sensitive fluorescent probe based on simple pyrazoline for Zn2+ in living neuron cells.

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  • 1Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, PR China.


We develop a pyrazoline-based fluorescent sensor for biological Zn(2+) detection. The sensor shows good binding selectivity for Zn(2+) over competing metal with 40-fold fluorescence enhancement in response to Zn(2+). The new probe is cell-permeable and can be used to detect intracellular zinc ions in living neuron cells.

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