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Anal Chem. 2012 Nov 6;84(21):9592-5. doi: 10.1021/ac302538j. Epub 2012 Oct 16.

Electrokinetic analysis to reveal composition and structure of biohybrid hydrogels.

Author information

  • 1Leibniz Institute of Polymer Research Dresden, Max Bergmann Center of Biomaterials Dresden, Hohe Strasse 6, 01069 Dresden, Germany. zimmermn@ipfdd.de

Erratum in

  • Anal Chem. 2013 Jan 15;85(2):1256.


Biohybrid hydrogels combining electrically neutral synthetic polymers and highly anionic glycosaminoglycans (GAGs) offer exciting options for regenerative therapies as they allow for the electrostatic conjugation of various growth factors. Unraveling details of ionization and structure within such networks defines an important analytical challenge that requires the extension of current methodologies. Here, we present a mean-field approach to quantify the density of ionizable groups, GAG concentration, and cross-linking degree of such hydrogels based on experimental data from microslit electrokinetics and ellipsometry. An exemplary poly(ethylene glycol)-heparin system was analyzed to demonstrate how electrostatic fingerprints of hydrogels obtained by the introduced strategy can sensitively display composition and structure of the polymer networks.

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