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Future Oncol. 2012 Sep;8(9):1157-65. doi: 10.2217/fon.12.93.

Detection of smell print differences between nonmalignant and malignant prostate cells with an electronic nose.

Author information

  • 1Medical School, University of Tampere, Tampere, Finland. antti.roine@uta.fi

Abstract

AIM:

To determine whether an electronic nose can differentiate cultured nonmalignant and malignant prostatic cells from each other and whether the smell print is secreted to the surrounding medium.

MATERIALS & METHODS:

Prostatic nonmalignant (EP-156T and controls) and malignant (LNCaP) cell lines, as well as conditioned and unconditioned media, were collected. The smell prints of the samples were analyzed by a ChemPro(®) 100 electronic nose device. The data were normalized and dimension reduction was conducted. The samples were classified and misclassification rates were calculated.

RESULTS:

The electronic nose differentiated the nonmalignant and malignant cell lines from each other, achieving misclassification rates of 2.9-3.6%. Cells did not differ from the conditioned medium but differed from the unconditioned medium (misclassification rates: 0.0-25.6%).

CONCLUSION:

Malignant and nonmalignant prostatic cell lines have distinct smell prints. Prostatic cancer cells seem to modify the smell print of their medium.

PMID:
23030490
[PubMed - indexed for MEDLINE]
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