Format

Send to:

Choose Destination
See comment in PubMed Commons below
PLoS One. 2012;7(9):e45471. doi: 10.1371/journal.pone.0045471. Epub 2012 Sep 19.

The role of nucleus accumbens core/shell in sleep-wake regulation and their involvement in modafinil-induced arousal.

Author information

  • 1State Key Laboratory of Medical Neurobiology, Shanghai Medical College of Fudan University, Shanghai, China. mhqiu@shmu.edu.cn

Abstract

BACKGROUND:

We have previously shown that modafinil promotes wakefulness via dopamine receptor D(1) and D(2) receptors; however, the locus where dopamine acts has not been identified. We proposed that the nucleus accumbens (NAc) that receives the ventral tegmental area dopamine inputs play an important role not only in reward and addiction but also in sleep-wake cycle and in mediating modafinil-induced arousal.

METHODOLOGY/PRINCIPAL FINDINGS:

In the present study, we further explored the role of NAc in sleep-wake cycle and sleep homeostasis by ablating the NAc core and shell, respectively, and examined arousal response following modafinil administration. We found that discrete NAc core and shell lesions produced 26.5% and 17.4% increase in total wakefulness per day, respectively, with sleep fragmentation and a reduced sleep rebound after a 6-hr sleep deprivation compared to control. Finally, NAc core but not shell lesions eliminated arousal effects of modafinil.

CONCLUSIONS/SIGNIFICANCE:

These results indicate that the NAc regulates sleep-wake behavior and mediates arousal effects of the midbrain dopamine system and stimulant modafinil.

PMID:
23029032
[PubMed - indexed for MEDLINE]
PMCID:
PMC3446879
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Public Library of Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk