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Proteomics Clin Appl. 2012 Dec;6(11-12):548-62. doi: 10.1002/prca.201200041. Epub 2012 Nov 8.

Functional protein microarray as molecular decathlete: a versatile player in clinical proteomics.

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  • 1Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, MD, USA. Heng.Zhu@jhmi.edu

Abstract

Functional protein microarrays were developed as a high-throughput tool to overcome the limitations of DNA microarrays and to provide a versatile platform for protein functional analyses. Recent years have witnessed tremendous growth in the use of protein microarrays, particularly functional protein microarrays, to address important questions in the field of clinical proteomics. In this review, we will summarize some of the most innovative and exciting recent applications of protein microarrays in clinical proteomics, including biomarker identification, pathogen-host interactions, and cancer biology.

© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

PMID:
23027439
[PubMed - indexed for MEDLINE]
PMCID:
PMC3600421
Free PMC Article
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