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Eur J Paediatr Neurol. 2013 Jan;17(1):7-13. doi: 10.1016/j.ejpn.2012.09.005. Epub 2012 Sep 29.

Cerebrospinal fluid biomarkers in neurological diseases in children.

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  • 1Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Neurochemistry, Sahlgrenska University Hospital/Mölndal, Göteborgsvägen 33, S-431 80 Mölndal, Sweden.


Analysis of cerebrospinal fluid (CSF) biomarkers is an integral part of neurology. Basic CSF biomarkers, such as CSF/serum albumin ratio and CSF cell counts, have been used to diagnose inflammatory and infectious CNS disorders in adults and children for decades. During recent years, however, numerous biomarkers for neuronal and astroglial injury, as well as disease-specific protein inclusions, have been developed for neurodegenerative disorders in adults. The overall aim of this paper is to give an updated overview of some of these biomarkers with special focus on their possible relevance to neurological disorders in children and adolescents.

Copyright © 2012 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.

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