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Physiology (Bethesda). 2012 Oct;27(5):300-7. doi: 10.1152/physiol.00023.2012.

Regulation of metabolism: a cross talk between gut microbiota and its human host.

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  • 1Institut National de la Santé et de la Recherche Médicale INSERM, Institut des Maladies Métaboliques et Cardiovasculaires, Toulouse, France. remy.burcelin@inserm.fr

Abstract

The recent epidemic of obesity and diabetes and the diversity at the individual level could be explained by the intestinal microbiota-to-host relationship. More than four million gene products from the microbiome could interact with the immune system to induce a tissue metabolic infection, which is the molecular origin of the low-grade inflammation that characterizes the onset of obesity and diabetes.

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