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Physiology (Bethesda). 2012 Oct;27(5):300-7. doi: 10.1152/physiol.00023.2012.

Regulation of metabolism: a cross talk between gut microbiota and its human host.

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  • 1Institut National de la Santé et de la Recherche Médicale INSERM, Institut des Maladies Métaboliques et Cardiovasculaires, Toulouse, France.


The recent epidemic of obesity and diabetes and the diversity at the individual level could be explained by the intestinal microbiota-to-host relationship. More than four million gene products from the microbiome could interact with the immune system to induce a tissue metabolic infection, which is the molecular origin of the low-grade inflammation that characterizes the onset of obesity and diabetes.

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