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Surg Clin North Am. 2012 Oct;92(5):1199-212. doi: 10.1016/j.suc.2012.07.011.

Management of gastroesophageal junction tumors.

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  • 1Department of Surgery, School of Medicine, University of Louisville, Louisville, KY 40202, USA.


Tumors of the gastroesophageal junction have historically been treated as either gastric or esophageal cancer depending on institutional preferences. The Siewert classification system was designed to provide a more precise means of characterizing these tumors. In general, surgical treatment of Siewert 1 tumors is via esophagectomy. Siewert 2 and 3 tumors may be treated with either esophagectomy with proximal gastrectomy or extended total gastrectomy provided negative margins are obtained. All but the earliest stage tumors should be considered for neoadjuvant chemoradiotherapy.

Copyright © 2012 Elsevier Inc. All rights reserved.

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