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J Med Virol. 2013 Jan;85(1):157-70. doi: 10.1002/jmv.23366. Epub 2012 Sep 28.

Full genomic analysis of a human rotavirus G1P[8] strain isolated in South Korea.

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  • 1Department of Microbiology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Abstract

A rotavirus G1P[8] strain C1-81 was isolated from a 5-month-old female infant admitted to hospital with fever and severe diarrhea in Incheon, South Korea. To investigate its full genomic relatedness and its group, the full genome of strain C1-81 was determined. Based on a full genome classification system, C1-81 was shown to possess the typical Wa-like genotype constellation: G1-P[8]-I1-R1-C1-M1-A1-N1-T1-E1-H1. On the basis of sequence similarities, the strain was shown to be the closest related strain to contemporary human rotavirus strains with recent strains isolated in Asia. This C1-81 strain showed the highest degree of nucleic acid similarity (98.8% and 97%) to G1 B4633-03 and P[8] (Thai-1604 and Dhaka8-02), respectively. This is the first report that group A rotavirus was analyzed with G1P[8] in South Korea. The study of the complete genome of the virus will help understanding of the evolution of rotavirus.

Copyright © 2012 Wiley Periodicals, Inc.

PMID:
23023979
[PubMed - indexed for MEDLINE]
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