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FEBS Lett. 2012 Nov 2;586(21):3900-7. doi: 10.1016/j.febslet.2012.09.021. Epub 2012 Sep 26.

Phosphorylation of measles virus phosphoprotein at S86 and/or S151 downregulates viral transcriptional activity.

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  • 1International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo, Japan.

Abstract

Measles virus phosphoprotein (P protein) is a cofactor of the viral RNA polymerase (L protein) that associates with the nucleoprotein-RNA complex to support viral transcription and replication. Here, we report a significant inverse correlation between the phosphorylation level of MV-P protein and viral transcriptional activity. Upregulation of P protein phosphorylation resulted in reduction of viral transcription. Additionally, we found that strong phosphorylation at S86 and S151 of P protein, which may be generally prevented by association with nucleoprotein, downregulates the viral transcriptional activity. These findings suggest that P protein is involved in regulation of viral transcription through changes in its phosphorylation status.

Copyright © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

PMID:
23022562
[PubMed - indexed for MEDLINE]
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