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Cytokine Growth Factor Rev. 2012 Dec;23(6):315-22. doi: 10.1016/j.cytogfr.2012.08.009. Epub 2012 Sep 28.

The emerging role of T cell cytokines in non-small cell lung cancer.

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  • 1Department of Medicine I, University of Erlangen-Nuremberg, Germany.


Non-small cell lung cancer (NSCLC) is among the most frequent types of cancer and associated with significant mortality. Recent studies suggest that tumor infiltrating T lymphocytes and their immunoregulatory cytokines play a fundamental role in controlling tumor growth and metastasis. Whereas T helper 1 cells and their master transcription factor T-bet have been identified as important regulators of IFN-gamma driven anti-tumoral immune response, IL-17 producing T helper 17 cells expressing RORA/C transcription factors have been found to augment tumor growth and cell proliferation in NSCLC. Furthermore, regulatory T cells were shown to impair immune responses against lung cancer. As modulation of T cell cytokines such as IL-17A has been recently shown to suppress tumor growth in experimental models, anti-cytokine agents emerge as a promising new approach for treatment of lung cancer.

Copyright © 2012. Published by Elsevier Ltd.

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