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Cell. 2012 Sep 28;151(1):11-3. doi: 10.1016/j.cell.2012.09.006.

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  • 1Department of Biochemistry, University of Cambridge, UK.


Myc is an enigma wrapped in a mystery. Attempts to identify Myc target genes, particularly in cancer, have been fraught with dead ends and context-specific functions. Lin et al. and Nie et al. address this conundrum by showing that Myc acts to amplify the output of existing transcriptionally active genes.

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